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Performing Translational Research to Combat RV Dysfunction and Pulmonary Arterial Hypertension
What we do:
The core interest of our lab is to define the molecular mechanisms that underlie right ventricular (RV) failure in pulmonary arterial hypertension (PAH). We implement a wide array of cutting edge molecular and physiological technologies in both small and large animal models to combat the molecular mechanisms underlying RV dysfunction.
![Prins Lab approaches](/sites/prinslab.umn.edu/files/2022-09/prins_lab_approaches.jpg)
We use translational experiments approaches to hopefully define therapeutic interventions.
Our research areas:
- Microtubule and t-tubule remodeling and its effects on RV function
- Evaluate mitochondrial metabolic dysfunction in RV failure
- Define how the microbiome impacts systemic inflammation and subsequently modulates RV function
- Use small and large animal models of RV failure and integrate multiple omics approaches with cutting edge physiological phenotyping
Recent publications:
- Prisco SZ, Hartweck L, Keen JL, Vogel N, Kazmirczak F, Eklund M, Hemnes AR, Brittain EL, and K.W. Prins. Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension. Front Cardiovasc Med. 2022 Aug 25;9:940932
- Prisco, SZ, L. Hartweck, L. Rose, T. Thenappan, S.L. Archer, and K.W. Prins. 2022. Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility, Circ. Heart Fail. Jan;15(1):e008574. doi: 10.1161/CIRCHEARTFAILURE.121.008574. Epub 2021. Editorial by Dr. Mann: Targeting Inflammation in Pulmonary Artery Hypertension: Is It Time for Forget the Lungs? https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.121.009290
- Prisco, SZ, M. Eklund, R. Raveendran, T. Thenappan, and K.W. Prins. 2021. With No Lysine Kinase 1 Promotes Metabolic Derangements and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension. JACC Basic Trans Sci, 11(11): 834-850. Editorial by Drs. Ha and Wende: Heart Failure in Pulmonary Arterial Hypertension Is Just a WNK1 Away: https://www.jacc.org/doi/10.1016/j.jacbts.2021.10.001
Open Positions:
We are building the Prins Lab and always looking to expand. We welcome applicants from all backgrounds and experiences.