Welcome to the Prins Lab

Performing Translational Research to Combat RV Dysfunction and Pulmonary Arterial Hypertension

What we do:

The core interest of our lab is to define the molecular mechanisms that underlie right ventricular (RV) failure in pulmonary arterial hypertension (PAH). We implement a wide array of cutting edge molecular and physiological technologies in both small and large animal models to combat the molecular mechanisms underlying RV dysfunction.

Prins Lab approaches

We use translational experiments approaches to hopefully define therapeutic interventions.

Our research areas:

  1. Microtubule and t-tubule remodeling and its effects on RV function
  2. Evaluate mitochondrial metabolic dysfunction in RV failure
  3. Define how the microbiome impacts systemic inflammation and subsequently modulates RV function
  4. Use small and large animal models of RV failure and integrate multiple omics approaches with cutting edge physiological phenotyping

Recent publications:

  1. Prisco SZ, Hartweck L, Keen JL, Vogel N, Kazmirczak F, Eklund M, Hemnes AR, Brittain EL, and K.W. Prins. Glyoxylase-1 combats dicarbonyl stress and right ventricular dysfunction in rodent pulmonary arterial hypertension. Front Cardiovasc Med. 2022 Aug 25;9:940932
  2. Prisco, SZ, L. Hartweck, L. Rose, T. Thenappan, S.L. Archer, and K.W. Prins. 2022. Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility, Circ. Heart Fail. Jan;15(1):e008574. doi: 10.1161/CIRCHEARTFAILURE.121.008574. Epub 2021. Editorial by Dr. Mann: Targeting Inflammation in Pulmonary Artery Hypertension: Is It Time for Forget the Lungs? https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.121.009290
  3. Prisco, SZ, M. Eklund, R. Raveendran, T. Thenappan, and K.W. Prins. 2021. With No Lysine Kinase 1 Promotes Metabolic Derangements and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension. JACC Basic Trans Sci, 11(11): 834-850. Editorial by Drs. Ha and Wende: Heart Failure in Pulmonary Arterial Hypertension Is Just a WNK1 Away: https://www.jacc.org/doi/10.1016/j.jacbts.2021.10.001

Open Positions:

We are building the Prins Lab and always looking to expand. We welcome applicants from all backgrounds and experiences.