Our core scientific interest is to define the molecular mechanisms that underlie right ventricular (RV) failure in pulmonary arterial hypertension (PAH). We focus primarily on the RV given its critical role in predicting long-term PAH outcomes.
Current Lab Projects
- Evaluate the effects of estrogen on microtubule remodeling and how it impacts RV function. (R01 HL158795)
- Determine how GP130 antagonism impacts RV function in a porcine model of RV failure. (R01 HL162927)
- Evaluate the how junctophilin-2 modulates the mechanisms underlying RV failure. (K08 HL140100)
- Investigate how the a dysregulated microbiome modulates inflammation and subsequent RV function.